A UFC Heavyweight Championship bout between Francis Ngannou and champion Stipe Miocic Functioned as If headliner.
The event also featured a UFC Light Heavyweight Championship bout between current champion Daniel Cormier and Volkan Oezdemir. 
A welterweight bout between The Ultimate Fighter: American Top Team vs. Blackzilians welterweight winner Kamaru Usman and Emil Weber Meek was originally scheduled for UFC 219. However, due to an alleged visa issue for Meek which affected his traveling schedule, the pairing was delayed and then rescheduled for this event.  However, it was shifted to UFC Fight Night: Stephens vs. Choi per day after, which took place six days before this event. 
A welterweight bout between Abdul Razak Alhassan and Sabah Homasi was originally scheduled for UFC 219, but later altered for this event. The pairing met at UFC 218, when Alhassan acquired via a TKO that was controversial. 
Charles Rosa was expected to face promotional novice Dan Ige. However, on December 22, Rosa pulled out injury.  Ige stayed on the card and faced fellow newcomer Julio Arce. 
Arnold Allen was expected to confront The Ultimate Fighter: Latin America 2 lightweight winner Enrique Barzola in the event. However, Allen was pulled from the fight on January 11 because of alleged visa problems which limited his ability to travel.  He had been replaced by newcomer Matt Bessette. 
Jamie Moyle was anticipated to confront Maryna Moroz at the event. However, Moyle pulled from the fight during the week leading up to case citing an undisclosed injury.  In turn, promotion officials indicated that Moroz would be rescheduled for a future occasion.
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